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KMID : 0939920080400040172
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대한암학회지
2008 Volume.40 No. 4 p.172 ~ p.177
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Clinical Characteristics and Treatment Results of Pediatric Osteosarcoma: The Role of High Dose Chemotherapy with Autologous Stem Cell Transplantation
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Lee Ji-Won
Kang Hyoung-Jin
Shin Hee-Young
Ahn Hyo-Seop
Park Sung-Hye
Kim Han-Soo
Kim Hye-Ri
Kim In-Won
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Abstract
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Purpose: In this study, we investigated the clinical characteristics and treatment results of osteosarcoma during the past 7 years, and evaluated the role of high dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT).
Materials and Methods: We retrospectively analyzed the clinical data of patients who were diagnosed as osteosarcoma at our center from January, 2000 to December, 2007.
Results: The 5-year overall survival and event-free survival of the patients were 72.6% and 55.9%, respectively. Seventeen (41.5%) patients showed disease progression during treatment or relapse after the end of treatment. The patients who had metastasis at diagnosis or who had a lower grade of necrosis after neoadjuvant chemotherapy showed decreased overall and event-free survival. Four patients received ASCT after HDCT, and 3 of them are alive without disease.
Conclusions: The patients who relapsed or had refractory osteosarcoma or who had metastasis at diagnosis or a lower grade of necrosis after neoadjuvant chemotherapy showed poor prognosis. HDCT with ASCT could be an alternative treatment option for these patients. (Cancer Res Treat. 2008;40:172-177)
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KEYWORD
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Osteosarcoma, Autologous stem cell transplantation, High dose chemotherapy, Pediatrics
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